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HelpTest Code LAB3982 Benzodiazepines Confirmation, Random, Urine
Ordering Guidance
For situations where chain of custody is required, a Chain-of-Custody Kit (T282) is available. For chain-of-custody testing, order BNZX / Benzodiazepines Confirmation, Chain of Custody, Random, Urine.
Additional drug panels and specific requests are available. Call 800-533-1710 or 507-266-5700.
Additional Testing Requirements
If urine creatinine is required or adulteration of the sample is suspected, also order ADULT / Adulterants Survey, Random, Urine in addition to this test.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Plastic urine container
Submission Container/Tube: Plastic, 5-mL tube
Specimen Volume: 1 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative
Additional Information:
1. No specimen substitutions.
2. STAT requests are not accepted for this test.
3. Submitting less than 1 mL will compromise our ability to perform all necessary testing.
Useful For
Detecting drug use involving benzodiazepines such as alprazolam, chlordiazepoxide, clonazepam, diazepam, midazolam, oxazepam, temazepam, clobazam, flunitrazepam, flurazepam, lorazepam, prazepam, triazolam, and zolpidem
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Benzodiazepines Confirmation, USpecimen Type
UrineSpecimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 7 days | |
| Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Icterus | Reject |
Reference Values
Negative
Cutoff concentrations by liquid chromatography tandem mass spectroscopy:
Alprazolam: 10 ng/mL
Alpha-hydroxyalprazolam: 10 ng/mL
Chlordiazepoxide: 10 ng/mL
Clonazepam: 10 ng/mL
7-Aminoclonazepam: 10 ng/mL
Diazepam: 10 ng/mL
Nordiazepam: 10 ng/mL
Midazolam: 10 ng/mL
Alpha-hydroxy midazolam: 10 ng/mL
Oxazepam: 10 ng/mL
Temazepam: 10 ng/mL
Clobazam: 10 ng/mL
N-Desmethylclobazam: 10 ng/mL
Flunitrazepam: 10 ng/mL
7-Aminoflunitrazepam: 10 ng/mL
Flurazepam: 10 ng/mL
2-Hydroxy ethyl flurazepam: 10 ng/mL
Lorazepam: 10 ng/mL
Prazepam: 10 ng/mL
Triazolam: 10 ng/mL
Alpha-hydroxy triazolam: 10 ng/mL
Zolpidem: 10 ng/mL
Zolpidem phenyl-4-carboxylic acid: 10 ng/mL
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80347
80339
80368
G0480 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| BNZU | Benzodiazepines Confirmation, U | 90890-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 608256 | Alprazolam by LC-MS/MS | 59615-5 |
| 608257 | Alpha-Hydroxyalprazolam by LC-MS/MS | 16348-5 |
| 608258 | Chlordiazepoxide by LC-MS/MS | 20522-9 |
| 608259 | Clonazepam by LC-MS/MS | 16229-7 |
| 608260 | 7-aminoclonazepam by LC-MS/MS | 51776-3 |
| 608261 | Diazepam by LC-MS/MS | 16227-1 |
| 608262 | Nordiazepam by LC-MS/MS | 16228-9 |
| 608263 | Midazolam by LC-MS/MS | 16233-9 |
| 608264 | Alpha-Hydroxy Midazolam by LC-MS/MS | 59590-0 |
| 608265 | Oxazepam by LC-MS/MS | 16201-6 |
| 608266 | Temazepam by LC-MS/MS | 20559-1 |
| 608267 | Clobazam by LC-MS/MS | 59635-3 |
| 608268 | N-Desmethylclobazam by LC-MS/MS | 97160-6 |
| 608269 | Flunitrazepam by LC-MS/MS | 20528-6 |
| 608270 | 7-aminoflunitrazepam by LC-MS/MS | 51777-1 |
| 608271 | Flurazepam by LC-MS/MS | 16231-3 |
| 608272 | 2-Hydroxy Ethyl Flurazepam by LC-MS/MS | 97159-8 |
| 608273 | Lorazepam by LC-MS/MS | 17088-6 |
| 608274 | Prazepam by LC-MS/MS | 17479-7 |
| 608275 | Triazolam by LC-MS/MS | 16232-1 |
| 608276 | Alpha-Hydroxy Triazolam by LC-MS/MS | 49876-6 |
| 608277 | Zolpidem by LC-MS/MS | 72770-1 |
| 608278 | Zolpidem Phenyl-4-Carboxylic acid by LC-MS/MS | 72768-5 |
| 608448 | Benzodiazepines Interpretation | 69050-3 |
Day(s) Performed
Monday through Friday
Report Available
2 to 6 daysForms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.