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Test Code LAB000 Immunoglobulin A (IgA) Heavy and Light Chain (HLC) Pairs, Kappa and Lambda with Ratio


Specimen Required


Specimen Type: Serum

Container/Tube:  Red top or SST

Specimen Volume: 0.75 mL

 

Collection Instructions: Draw blood in a plain red-top tube, serum gel tube(s) is also acceptable. Separate serum immediately after coagulation (30 minutes) to prevent hemolysis. Send 0.75 mL of serum refrigerated in a plastic vial.

 

NOTE: Patient should be fasting for eight hours to avoid lipemic sample interference.


Useful For

For the quantitative measurement of human IgA heavy chain and light chain intact immunoglobulin in serum. The result can be used when monitoring previously diagnosed IgA multiple myeloma patients and is used in conjunction with other clinical and laboratory findings.

Heavy and light chain pair quantitation may be useful for:

1. Distinguishing between broadly migrating monoclonal proteins and restricted polyclonal immunoglobulin patterns on serum protein electrophoresis.

2. Quantitating monoclonal IgA proteins that are difficult to quantitate using serum protein electrophoresis alone.

3. Providing a more specific quantitation of the monoclonal protein than total IgA measurements alone.

Reporting Name

IgA Heavy Light Chains (HLC), S

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reject Due To

Hemolysis Mild reject; Gross reject
Lipemia Mild reject; Gross reject
Icterus NA
Other Microbially-contaminated specimen; specimen containing particulate matter

Reference Values

IgA Kappa (g/L): 0.48-2.82

IgA Lambda (g/L): 0.36-1.98

IgA Kappa:IgA Lambda ratio: 0.80-2.04

Day(s) Performed

Tuesday, Friday

Report Available

1 to 9 days

Performing Laboratory

LabCorp Burlington

CPT Code Information

83883 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FHLCA IgA Heavy Light Chains (HLC), S 74773-3

 

Result ID Test Result Name Result LOINC Value
Z5616 IgA Kappa, S 74864-0
Z5617 IgA Lambda, S 74865-7
Z5618 IgA K/L HLC Ratio 74869-9

Method Name

Turbidimetric